Effective Anti-Histamine Research stated that Quercetin is very effective anti-histamine which can block the cells to receive the histamine from outside stimulation. Histamine is a protein which can initiate nasal congestion, sneeze, running nose, tearful eyes and other allergic responses. Quercetin can alleviate the symptoms from the allergic reactions including nasal congestion, sneeze, running nose, tearful eyes and itching skin.